Jody F. Lyda, 35, of Macon was fatally injured on Tuesday at 6 a.m. in a two-vehicle accident on Highway 15, five miles north of Plevna in Knox County.
According to the Missouri State Highway Patrol, Lyda was a passenger in a southbound 1994 Chevrolet S10 driven by Lucas R. Smith, 32, of Shelbyville.
Lucas' vehicle was struck head on in the southbound lane by a northbound 1998 GMC Sonoma driven by Marvin S. Horst, 44, of Novelty.
Smith suffered serious injuries and was flown by helicopter to University of Missouri Hospital in Columbia.
Horst was taken to Northeast Regional Medical Center in Kirksville with what appeared to be minor injuries.
None of the individuals were wearing seatbelt, according to the report.
The patrol was assisted at the scene by the Major Crash Unit, Knox County Sheriff's Office and Knox County Fire and Rescue.
Services for Lyda are pending at Greening, Eagan Hayes Funeral Home in Macon.